Typhoid Fever Essay examples - 1759 Words

Typhoid Fever Typhoid fever is an intestinal illness, which can result in great suffering and even death. At first it was commonly confused with other fever causing illnesses until 1869 when William Jenner performed a careful analysis and found differences in the different types of typhus fevers. In this paper, I will discuss the bacteria that causes typhoid fever, discuss the signs, symptoms, method of transmission, past and current epidemics, and whether or not there has been a decrease in outbreaks in the past few years. Typhoid fever is caused by the bacterium Salmonella typhi, a member of the genus Salmonella, which is included in the Enterobacteriaceae family. Salmonella typhi cells are aerobic, gram negative rods that†¦show more content†¦If the immune system is unable to stop the infection, the bacterium will multiply and then spread to the bloodstream, after which the first signs of disease are observed in the form of fever. The bacterium penetrates further into the bone marrow, liver, and bile ducts, from which bacteria are excreted into the bowel movements. (Easmon 2003) The second phase of the disease involves the bacteria entering the immune tissue of the small intestine. This causes vomiting and diarrhea, often described as pea soup. If left untreated, the bacteria can create a hole in the small intestine, causing intestinal matter to flood the abdominal area. If one is lucky enough to survive this illness without treatment, he or she can still be a carrier of the germs long after the symptoms have disappeared. The bacteria have an ability to fight the normal bodily process of eliminating germs. Recently, the mechanism used by the bacteria to avoid detection has been identified. The typhoid bacteria use a protein to kill macrophages, which are our first defense against infection. Without these macrophages, infection goes unnoticed into the body. (sciencedaily.com) Killing these macrophages is the key to survival for the typhoid bacteria. Researchers identified in mouse cells a protein kinase called PKR that causes the death of this macrophage, or large white blood cells that act as the bodys first defense againstShow MoreRelatedPathology of Typhoid Fever Essay899 Words   |  4 PagesGenerally a fever is associated with a common cold, but in some cases a fever can be one of the symptoms of the deadly disease Typhoid fever. Typhoid fever is caused by the bacterium Salmonella Typhi. It is most common in underdeveloped countries but many cases have appeared in the United States and ma ny Western countries. In some places, Typhoid fever is the leading killer of people. There are key symptoms to look out for, many ways to diagnose it, different treatments, and a hopeful prognosisRead MoreTyphoid Fever and Contrast Organizer6812 Words   |  28 Pageswill begin Segment 3 by drafting an outline of the main points that both compare and contrast â€Å"Typhoid Fever† and â€Å"The Education of Frank McCourt.† Please note, for this segment, you are not writing an entire essay. You are filling out the Compare and Contrast Organizer. Make sure to answer the following in your organizer, using complete sentences: †¢ List two main points discussed in â€Å"Typhoid Fever.† What was the story about? What should a reader take from the story? †¢ List two main points discussedRead MoreThe Communicable Disease Typhoid Fever1523 Words   |  7 Pagesdisease typhoid fever, which affects a plethora of people in India every year. I choose to propose this communicable disease because of my grandfather, whom is an advocate for increase funding against this terrible disease. In my paper I would like to compare and contrast the developing country, which is India to the USA. I would like to compare and contrast how typhoid fever affects each country every year, what the government does to control typhoid fever and the cultural effects typhoid fever hasRead MoreThe Outbreak Of Cholera Fever1274 Words   |  6 Pages One year earlier, in 2010, multistate outbreak of human typhoid fever infections associated with frozen mamey fruit pulp caused 9 infections, 5 of which were from California, and 4 of which from Nevada. All of those patients were hospitalized, and none of them died from the infection. On  August, 2010,  Goya Foods, Inc. and Montalvan’s Sales, Inc. announced voluntary recalls of frozen mamey pulp. Typhoid fever is caused by Salmonella  serovar Typhi, which is associated with food and water that haveRead MoreEssay On Systemic Enteric Fever719 Words   |  3 PagesGeneralized systemic enteric fever, headache, malaise, anorexia, enlarged spleen, and constipation followed by more severe abdominal symptoms; rose spots on trunk in 25% of Caucasian patients; complications include ulceration of Peyers patches in ileum, can produce hemorrhage or perforation; Common enterocolitis may result without enteric fever; characterized by headache, abdominal pain, nausea, vomiting, diarrhe a, dehydration may result; case fatality of 16% reduced to 1% with antibiotic therapy;Read MoreJudith Walzer Leavitts Typhoid Mary Essay1345 Words   |  6 Pages Judith Walzer Leavitts Typhoid Mary details the life of Mary Mallon, one of the first known carriers of the typhoid disease. Leavitt constructs her book by outlining the various perspectives that went into the decisions made concerning Mary Mallons life. These perspectives help explain why she was cast aside for most of her life and is still a household catchphrase today. Leavitt paints a picture of the relationship between science and society and particularly shows how MallonRead MoreTyphoid Fever Frank Mccoourt Analysis765 Words   |  4 PagesTyphoid Fever Versus The Education of Frank McCourt The first main point in the story Typhoid Fever is that literature can have everlasting impact on people’s lives. In the story, Patricia reads â€Å"The Highwayman† poem to Frankie. Because the children are not allowed to talk to each other, Patricia reads bits and pieces to Frankie at different times to avoid being caught. Frankie is awaiting the next part of the poem when he learns that Patricia has passed away. He is very disappointed because he neverRead MoreFrank Mccourt and the Value of Misery1061 Words   |  5 Pagesshould have had to endure. After losing his baby sister Margaret and twin brothers Eugene and Oliver, to disease and bad parenting, McCourt went through terrible times himself. Regullary subject to malnutrition and neglect, he came down with the typhoid fever, spending weeks in the hospital, and an unrecognized, persistent eye infection that came close to blinding him. McCourt grew up learning his life s ugly lessons as a child. From his birth, McCourt was left in an environment in which he hadRead MoreFood Born Illness Essay2279 Words   |  10 Pagesthat tie both cases together are that typhoid was spread by some form of contaminated food by a person (milk, food, water, seafood). In the case of Typhoid Mary, it was spread by her handling the food improperly. She was a carrier, and thus when she did not use good sanitary food preparation skills (like washing of hands), she passed the typhoid along to others. In the second case in Schenectady, New York, water did not seem to play a part in the spread of typhoid. So in both of these cases, the keyRead MoreWhy Are Salmonella Typhi?1089 Words   |  5 Pages which causes systemic infections and Typhoid fever in human beings. It is rod shaped and is flagellated and inhabits the lympathic tissues of the small intestine, liver, spleen, and bloodstream of infected humans. This bacterium belongs to the family Enterobacteriaceae. There have been typhoid fever outbreaks in many different countries including United States of America, Canada and Uganda. Being Uganda the most recent place to have an epidemic for typhoid, I will discuss about this particular outbreak

Gateway Drugs - 3897 Words

Gateway Drugs and Common Drug Abuse The oldest known written record of drug use is a clay tablet from the ancient Sumerian civilization of the Middle East. This tablet, made in the 2000 s B.C., lists about a dozen drug prescriptions. An Egyptian scroll from bout 1550 B.C. names more than 800 prescriptions containing about 700 drugs. The ancient Chinese, Greek and Romans also used many drugs. The Greeks and Romans used opium to relieve pain. The Egyptians used castor oil as a laxative. The Chinese ate liver to cure anemia. In the 1500,s and 1600 s, doctors and scientists made important advances in Pharmacology and in other fields of science. In the early 1500 s, Swiss physician Philippus Paracelsus pioneered in the use of minerals†¦show more content†¦Bad trips and flashbacks are only part of the risks of LSD use. LSD users may manifest relatively long-lasting psychoses, such as schizophrenia or severe depression. It is difficult to determine the extent and mechanism of the LSD involvement in these illnesses. Schreiber 3 Most users of LSD voluntarily decrease or stop its use over time. LSD is not considered an addictive drug since it does not produce compulsive drug-seeking behavior, as do cocaine, amphetamine, heroin, alcohol, and nicotine. However, like many of the addictive drugs, LSD produces tolerance, so some users who take the drug repeatedly must take progressively higher doses to achieve the state of intoxication that they had previously achieved. This is an extremely dangerous practice, given the unpredictability of the drug. MDMA (Ecstasy) MDMA is a synthetic, psychoactive drug with both stimulant (amphetamine-like) and hallucinogenic (LSD-like) properties. Street names for MDMA include Ecstasy, Adam, XTC, hug, beans, and love drug. Its chemical structure (methylenedioxymethamphetamine, MDMA) is similar to methamphetamine, methylenedioxyamphetamine (MDA), and mescaline - other synthetic drugs known to cause brain damage. MDMA also is neurotoxic. In addition, in high doses it can cause a sharp increase in body temperature (malignant hyperthermia) leading to muscle breakdown and kidney and cardiovascular system failure. Brain imaging research in humans indicates that MDMA causes injury to theShow MoreRelatedThe Gateway Drug1517 Words   |  7 PagesNaloxone: The Gateway Drug Classified as an antidote, naloxone gives individuals who overdose on opioids a second chance at life, but without access to proper treatment, these users will continue living in the cycle of addiction until either finding enough strength to pull through the recovery process or falling victim to life’s only certainty prematurely. In response to the ever-growing opioid epidemic in the United States, many elected officials, health-centered agencies and addiction support groupsRead MoreMarijuana: A Boon or A Gateway Drug876 Words   |  4 Pagesis the most popular drug plant. These products often used for their psychoactive effects. This can include heightened mood or euphoria, relaxation, and an increase in appetite. Popularity of the marijuana has increased widely these days between all age groups. Smoker’s says, â€Å"There is no harm in smoking marijuana, as it is non-addictive, it relaxes your body and connects you to your soul whereas, non-smokers say, â€Å"There is no reason one should smoke it because it’s a gateway drug.† Those who have neverRead MoreMarijuan The Gateway Drug1595 Words   |  7 PagesCannabis; the gateway drug to harder narcotics or mankind’s unused saviour? Is cannabis as bad as we are led to believe or is it an untapped natural resource that the higher powers refuse to acknowledge? Since 1928 cannabis has been illegal in the United Kingdom. However it is also the most extensively used drug within the UK. This naturally found plant is known around the world, mainly for giving its users a ‘high’ however what many people don’t know is that this plant has also been tested andRead MoreMarijuana as a Gateway Drug2211 Words   |  9 PagesSociology 225 Research Paper Marijuana as a Gateway Drug The gateway theory is a hypothesis which states that the use of gateway drugs (alcohol, tobacco and marijuana) lead to the use of more illicit drugs such as heroin and cocaine. According to the Drug Enforcement Administration (DEA), marijuana is a Schedule I substance under the Controlled Substances Act. â€Å"Schedule I drugs are classified as having a high potential for abuse, no currently accepted medical use in treatment in the United StatesRead MoreMarijuana a Gateway Drug?906 Words   |  4 PagesMarijuana Is a Gateway Drug First time marijuana use will lead to harder drugs, creates health risks including HIV. Earleywine, M. (2004). Marijuana Is Not a Gateway to Other Addictive Drugs. Most marijuana users do not touch hard drugs. First time marijuana use does not mean an individual will use harder drugs because people will use whatever drug is available when they are ready to experiment. According to data from the 2000 National Household Surveys on Drug Abuse (NHSDA)Read MoreEssay on Pros and Cons of Legalizing Marijuana557 Words   |  3 Pagesand should be illegal, and some people think it is good in some ways if used properly. It should be legal because it has few negative effects, it serves other purposes than getting people stoned, and it is better than other drugs. Many advocates say â€Å" Marijuana is a common drug used by many people.†(Sandra) A lot of people think marijuana has numerous amounts of negative effects on the body. Marijuana helps the body in many different ways. It relaxes and relives stress from many people. It has beenRead MoreThe Drug Marijuana916 Words   |  4 PagesMarijuana is one of the most commonly abused drugs around the world and is categorized by the US Drug Enforcement Agency as a schedule I drug. This means it has a higher chance of being abused. (â€Å"Legalization of marijuana: potential impact on youth† 1825). Those who are in support of legalizing marijuana do not understand the negative effects of legalizing marijuana and marijuana use itself. There are several arguments for legalizing marijuana, however, the reasons for keeping it illegal outweighRead MoreShould Marijuana Be Legalized?890 Words   |  4 Pagesimpair cognition and increase the risk for psychiatric diseases, such as schizophre nia.† (1) May cause death. In similar circumstances, people who advocate against marijuana being legalized may talk about, how marijuana is a gateway drug and if marijuana is legalized than drug use among kids will increase drastically. The position that I just stated is wrong and here’s why. What if your son or daughter or mother is passing away and the only thing that will assist them live little longer is marijuanaRead More paper1625 Words   |  7 Pageshow many deaths come from tobacco and alcohol about a half million. That is only deaths that doesn’t say how many people have lip cancer and things that aren’t going to kill them. People say marijuana is addicting, but marijuana is not an addicting drug. People who smoke marijuana feel relaxed, and also laugh more then usual. I don’t know why you laugh more but it is true. When using marijuana you do get less coordinated and don’t perform many things as well as when not high. As long as p eople dontRead MoreHayden Hines. Prof. Hawk. Comp 2. 9 Am-9:50 Am. 5 May 2017.1040 Words   |  5 Pagesgiven 30+ years of prison time. A popular belief today is that marijuana should be categorized as a harsh drug that produces a health hazard and if caught with it, deserves a harsh penalty and should in most cases be considered a gateway drug. A gateway drug is something that people see as a drug that isn’t as hard-core as others, but using this drug may lead some to try even more dangerous drugs because eventually they will need something more intense than the high that marijuana gives them. While

Critical Thinking and Managerial Decision Making

Question: Describe about the "Critical Thinking and Managerial Decision Making". Answer: Introduction The critical thinking concerns with a disciplined channel of thinking, which is rational, clear, open-minded and guided by evidence. The objective of critical thinking is to form a strong base of informed decision making. The critical thinking allows individuals to induce a broad thinking capability, which would aid them in taking crucial decisions in professional life as well as personal life. The critical thinking enhances the reasoning ability of an individual. The critical thinking is a characteristic feature of the active learners. There are many characteristics of the critical thinkers, which help them in a professional scenario. They are able to understand the connecting links between ideas, determine the importance of ideas, recognize arguments and approach any given problem in a systematic manner. The critical thinkers are able to identify any inconsistencies in the reasoning process and evaluate any errors in the reasoning process. They can provide valid justification of th eir values, beliefs and own assumptions. The critical thinkers can take crucial decisions within a short period of time. Discussion The critical thinking deals with the enhancement of the thought process beyond the everyday way of thinking. I have benefitted from the course on critical thinking and managerial decision making. I have acquired skills, which are required for becoming a successful manager. I can clearly understand the various situations in day to day life. I can make accurate and faster conclusions from specific problems and make good decisions. I can avoid mistakes and can recognize untapped opportunities easily. I have learned that for the purpose of effective decision making, three things are essential- Clarity, Conclusions, and Decisions. I have learned that my thinking can be purposeful and realized that sometimes I become partial in my thinking process. I have learned from the course that I should consider other peoples perspective too and avoid biases in the decision making process. I have learned to organize my thoughts and incorporate other's thinking before arriving at a decision. I have realized the importance of clarity of thoughts in a day to day life. I have started to open up my mind and accept any form of feedback or conversation with open arms. When I confront problems, I have started to inspect the problem thoroughly, which eliminates any associated ambiguity. I try to follow a smooth transition in between clarity and conclusions. I have started to believe in the fact that there is a need to increase the intellectual capacity of the brain. I engage myself in clearing my cluttered feelings; calm myself down in times of distress and getting rid of negative thoughts. I have observed that negative thoughts t end to clog my brain and I am unable to undertake vital decisions. I have decided to stop letting the negative thoughts from establishing themselves in my brain. The positive thoughts help me to have a clear channel of thoughts and hence help me in taking better decisions. I have learned to create a vision in my professional endeavors. A vision helps me to clarify the purpose, list of problems to solve and the duration for achieving the goals. It provides day to day guidance to me in achieving my goals. I have observed benefits of clarifying my thoughts process, especially in my workplace. I have started focusing on my gains, more than focusing on my losses. The ability to concentrate on the gains helps me to analyze myself in a better way. It helps me to focus on the objectives and goals of my personal life as well as professional life. There is a need to have a clear idea of the mission of my organization. The main objective of clarity is the ability to solve crucial problems or issues. I have started to look creatively at the situations which revolve in my day to day life. I have started looking at situations from multiple angles and the potential solutions. I have started to consider all the premises about a particular situation and then arrive at a conclusion. I did not consider these premises earlier, and hence my decision making process was not complete. After reading the course, I have learned to consider facts, observations, experiences and assumptions for drawing a conclusion. I have learned that a strong premise should be developed for deriving a good conclusion. A good conclusion or a good decision would give good results. I need to negotiate with the concerned persons and understand their assumptions. The course also made me understand the credibility of a premise. The premise should be realistic, feasible, gained from a reliable source, verifiable and consistent with my existing knowledge. I have also started to consider all the available premises and variables before arriving at a particular conclusion. It is not wise to make conclusions based on the few facts or incomplete information. The decision making process can be best achieved by the consideration of all available information. In an organization, there is a need to do thorough data collection and data analysis before arriving at a conclusion or decision. The course helped me to understand the importance of self-awareness. I came to know that self-awareness is the key to good leadership. I strive to be a good leader in my workplace and hence I should have knowledge of my attitudes, feelings, desires, strengths and motives. I have learned that self-awareness can be created by feedback from others, reflecting my feelings, admitting mistakes, aware of my emotions and others. I have imbibed the wonderful concept of Johari Window and applied the same to understand my relationship with my inner self and with others. I understood how knowledge about self and others could be developed effectively by focusing on specific factors like self-efficacy and self-esteem. I have started to establish a relationship with others based on trust. I have learnt the importance of self disclosure, which can help in creating a mutual harmony between the team members. I have learnt from the Johari Window that I need to increase the vastness of the open area, wi thout the disclosure of excessive personal information. I have learnt that the open area is the most crucial area, which is essential for being more productive, effective and cooperative. The open area is the underlying principle of the give and take procedure that happens between other people and me. The Johari Window is an excellent visual tool to analyze myself as well establishes my relationship with others. It helps me to take better control of my decisions and be confident about my decisions. I have learned that the contexts are important in making my decision making more effective. When I am bombarded with situations, the first things that I should consider are analyzing the situations and select a particular context to which I should direct my decisions. There can be several contexts to a single situation like simple, complicated, complex, chaotic and unclear. In business worlds, I need to understand that there is no one single decision maker. I cannot take a decision alone in the corporate world, and there are several authorities involved in it. I should calculate all the possible risks that can arise from a particular situation before I take the final call. I am striving in a dynamic world, in which I would be exposed to psychological contracts. I have studied the features of psychological contracts such as voluntary choice, belief in agreement, multiple contract makers and others. I have learned to improve my disaster management skills. I have learned ways to manage the incurred losses from a failed contract. The negative emotions arising from the failure of a contract needs to be handled, and I have successfully learned how to manage failures. I have improved my skills of loyalty and stability, which are essential components of relational contracts. I have also learned the role of my employer in the employee management practices. I need to take an active part in the organizational change management and strive to get the best out of the people. One of the important characteristics of a manager is the analysis of potential risks. I have learned the importance of categorizing the risks according to priority and the probability of occurrence. There is also need to evaluate my strengths and weakness, which would help me to convert my identified weakness into strengths. The course also gave an outline to debating practices, roles, etiquettes, positioning, sequences and others, which are important components in the corporate world. The Reflect tool is very useful for gaining a clear understanding of me and the way I am perceived by others. I learnt to identify my own positive traits and my level of commitment towards my professional as well as personal growths. I got a clear picture about my approach to various challenges and the way I interact with my team mates or another person. I have created a personal development plan, which helps me to achieve my goals easily. It would help me to improve my emotional intelligence so that the objectives are fulfilled. The videos helped me to learn about game theory. They help me to understand the rules of competition and cooperation, which are important components in the corporate scenario. I learnt about added values, rules, and tactics for surviving in professional as well as personal life. Conclusion The course was helpful in shaping my mental abilities. The decision making ability is the most important feature of an individual. I have successfully implemented the learning of the course in real life. It has made me aware of myself and changed my way of thinking. I can take effective decisions in the least possible time, after going through the course.

The Libyan Conflict

Table of Contents Introduction Parties in the Libyan Conflict Conclusion Reference List Introduction The Libyan conflict pits the supporters of the Libyan leader, Muammar Gaddafi, on one side and the anti-Gaddafi forces backed by the international community. It began as peaceful protests that later degenerated into a rebellion after use of excessive force on the protesters by the supporters of the government opposed to the revolution. Both sides of the Libyan conflict struggle to gain control of the country’s leadership.Advertising We will write a custom article sample on The Libyan Conflict specifically for you for only $16.05 $11/page Learn More What began as peaceful protests against the autocratic regime, degenerated into a full-blown conflict that has even attracted involvement from the international community. The perception of the citizens that the regime is oppressive and dictatorial encouraged the mass protests. The pro-government for ces on the other hand are opposed to the perceived involvement of the international community and the Western countries to impose regime change in their country. Parties in the Libyan Conflict The conflict started with low-level protests against the government, which retaliated with violence against its citizens. The protesters gradually gained support even from within the â€Å"pro-Gaddafi community leading to the establishment of the Transition National Council based in Benghazi† (Cimmino, 2011). The main interest of staging the revolt was to topple the oppressive regime and establish a democratic rule. The response of the Libyan leader and his supporters opposed to this revolt involved use of excessive force to quell the violence. However, the protesters have gradually continued to gain support from the citizens and the international community. The international community’s involvement is to protect the civilians and establish a peaceful environment to settle the co nflict. The incompatible goals in this conflict lie in the opposition to Gaddafi’s oppressive rule. The government’s counteroffensive response characterized by heavy use of military weapons and threats by the pro-government forces against the rebels show the government’s determination to remain in power moreover; the government also censored communication media including the social media for fuelling the conflict. The protesters want to end the oppressive and corrupt regime that is accused of infringement of human rights. The conflict was fueled by poor economic theories coupled with corruption and tribalism, which have contributed to low living standards of the citizens despite the country’s rich oil reserves. The conflict underwent an escalatory spiral from a peaceful protest to violent conflict attracting the involvement of the international community (Folger, Poole, Stutman, 1997, p.67). Initially, most Libyans manifested the avoidance cycle, as they feared the conflicts would turn out to be costly. However, after the government’s violent response to protests, many joined forces with the rebels.Advertising Looking for article on government? Let's see if we can help you! Get your first paper with 15% OFF Learn More According to the Lens model, the protesters perceive the Gaddafi’s rule as oppressive and corrupt and ought to be replaced with a democratic leadership (Dana, 2001, p.123). On the other hand, the Gaddafi leadership perceives the protesters as motivated by the West and thus resists any attempt to topple him from power. The conflict spread starting from the Western cities involving Libyan citizens of all cultures and of both gender. Conclusion In a conflict, various parties are influenced to participate by taking sides based on the current perceptions of the issues past or present. The parties involved in a conflict tend to respond based on their perceptions of the situation. In Libya, the co nflict involves the government forces and the anti-government rebels who want to topple the regime based on their perception of the regime as corrupt and oppressive. The Lens model facilitates an objective view to a conflict by both of the involved parties in order to arrive at peaceful agreement. Reference List Cimmino, R. (2011). North Africa Revolution Series: Libya. 30/03/2011. Retrieved from https://oneaggieland-blog.tumblr.com/post/4064234449/north-africa-revolution-series-libya Dana, D. (2001). Strategy of Conflict Resolution. New York: McGraw Hill. Folger, P., Poole, S., Stutman, K. (2001). Working Through Conflict: Strategies for Relationships, Groups, and Organizations. New York: Addison Wesley Longman Press. This article on The Libyan Conflict was written and submitted by user Averi Dunlap to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

Lab Report- Neurophysiology of Nerve Impulses Essay Example

Lab Report- Neurophysiology of Nerve Impulses Paper Neurons (also known as neurons, nerve cells and nerve fibers) are electrically excitable and the most important cells in the nervous system that functions to process and transmit information. Neurons have a large number of extensions called dendrites. They often look likes branches or spikes extending out from the cell body. It is primarily the surfaces of the dendrites that receive chemical messages from other neurons. One extension is different from all the others, and is called the axon. Although in some neurons, it is hard to distinguish from the entries, in others it is easily distinguished by its length. The purpose of the axon is to transmit an electro-chemical signal to other neurons, sometimes over a considerable distance. Longer axons are usually covered with a myelin sheath, a series of fatty cells which have wrapped around an axon many times. They serve a similar function as the insulation around electrical wire. At the very end of the axon is the axon ending. It is there that the electro-chemical signal that has traveled the length of the axon is converted into a chemical message that travels to the next neuron. (Dry. C. George Before, 2009). Axons are what make up nerves. We will write a custom essay sample on Lab Report- Neurophysiology of Nerve Impulses specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Lab Report- Neurophysiology of Nerve Impulses specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Lab Report- Neurophysiology of Nerve Impulses specifically for you FOR ONLY $16.38 $13.9/page Hire Writer A nerve is a bundle of neurons fibers or processes wrapped in connective tissue that extends to and/or from the CONS and visceral organs or structures of the body periphery (Marine Mitchell, 2009). In this experiment we will work with a nerve The action potential we will see on this experiment reflects the cumulative action potentials of all the neurons in the nerve, called a compound nerve action potential. Although an action potential follows the all-or none law within a single neuron, it does not necessarily follows the all-or-none law within an entire nerve. When you electrically stimulate a nerve at a given voltage, the stimulus may result in deportation of most of the neurons but not necessarily all of them. To achieve deportation of all of the neurons, a higher stimulus voltage may be needed ( Marine Mitchell, 2009). Seaplanes in the body all begin with the resting membrane potential. This is the natural state of a nerve before it is presented with a stimulus (Martini, Nathan Bartholomew, 2012). Resting membrane potential is important because it is necessary in order for a synapse to occur (Marine Mitchell, 2009). This resting Tate stands at -map because of three factors. First the ionic composition of the extracurricular and intracellular fluid varies in their charge. The Extracurricular fluid has a negative charge because of the An+ ion that exist, just as the intracellular fluid has a negative charge because of K+ ions and negatively charged proteins (Martini, Nathan Bartholomew, 2012). Second the cells have an uneven distribution because of the existence of sodium and potassium leak channels. This allows the creation of an electrochemical gradient, which ultimately is the force that guides the conduction of an action potential. The electrochemical gradient is created by sodium-potassium pump which is responsible for exchanging 3 An+ ions out while bringing in 2 K+ ions (Martini, Nathan Bartholomew, 2012). Third, the resting membrane potential varies in permeability based on the type of ion. Membranes are more easily permeable by K+ ions because of their size, which is responsible for the negative charge during the resting state (Martini, Nathan Bartholomew, 2012) Without a resting potential, we would not have a threshold to conduct an action potential. When a stimulus is presented, it requires a certain excitability, or popularization level of at least map to map (Martini, Nathan Bartholomew, 2012). The action potential depends on the threshold stimulus because of the all or none principle. This states that if a stimulus does not break the required threshold level, no action potential will occur (Martini, Nathan Bartholomew, 2012). However, if a threshold does uphold this principle, an action potential is created and a synapse begins. When membrane is exposed to a certain chemical, its response is either excited or inhibited. When a membrane is excited deportation begins. When the membrane depilatories the resting membrane potential of -70 NV becomes less negative. When the membrane potential reaches 0 NV, indicating there is no charge difference across the membrane. The sodium ion channels start to close and potassium ion channels open. By the time the sodium ion channels finally close. The membrane potential has reached +35 NV. The opening of the potassium channels allows K+ to flow out of the cell down its electrochemical gradient ( ion of like charge are repelled from each other). The flow of K+ out of the cell causes the membrane potential to move in a negative direction. This is preferred to as revitalization. ( Marine Mitchell, 2009). As the transmigrate potential comes back down towards its resting potential level and the potassium channels begins to close, the transmittance potential level goes just below -map, causing a brief period of hyperventilation (Martini, Nathan Bartholomew, 2012). Finally, as the potassium channels close, the membrane turns back to its resting potential until it is excited or inhibited again. In this experiment we will be dealing with two chemicals that intend to inhibit a nerve impulse. Curare is a toxic substance that interferes with the neural remission between motor neurons and skeletal muscles. Curare competes with acetylenes -or Ach- for receptors on muscle cells. Acetylenes is a chemical messenger that normally transmits nerve impulses and activates muscles receptors. Schaeffer, 2010). Loading is a chemical substance that inhibits the transmission of nerve impulses by blocking An ion flux across nerve membranes. In other words Loading is a local anesthetic that blocks voltage- gated An channels at low concentrations, it would make it harder to reach the threshold for firing action potential at high concentrations, and it would stop the action potential entirely. Materials/ Methods This experiment was conducted using the lab manual Human Anatomy Physiology by Marine Mitchell, 2009. Exercisers neurophysiology of Nerve Impulses on Physiology 8. 0 page 131 The activities that were used in this exercise were o Activity 6- testing the Effects of curare page 131 o Activity 7- Testing the Effects of Loading page 131 Results Effects of Curare versus Loading on a Nerve Voltage (NV)Action Potential Notes Curare 2. 0 NV Inaction potential begins at 3. NV Amplitude increases by very little and remains constant soon after. 3. 0 NV Yes 4. NV yes Loading 2. 0 NV No No action potential is recognized 3. NV No 4. NV No Using a frog nerve, two inhibitory chemicals were place onto the nerve to determine what inhibitory properties were seen after stimulating at the threshold voltage for this nerve. Discussion To have a better understanding of the respond to a stimulus and action potential of a nerve (In this case a frog sciatic nerve) we executed this experiment, and realized that numerous physical and chemical factors can impair the ability of a nerve to function. On the first exp eriment we used Curare that at 3. NV created an action attention on the nerve. At the neuromuscular junction, the action potential occurs in the presentation motor neuron, which releases acetylenes during an action potential. Synapses is a junction between two neurons. The presentation neuron terminal is the one that releases a neurotransmitter in response to an action potential. The posthypnotic neuron is the one that receives the neurotransmitter and may undergo an action potential (and become a presentation to the next nerve cell) if the neurotransmitters stimulate the cell enough. When curare is present, it will block acetylenes from binding to its acceptors on the muscle fiber, in turn stopping the muscle from contracting. They key point is that this effect is exclusively post synaptic. The presentation neuron still fires the identical action potential with or without the drug, it still release neurotransmitter. When curare is present, only the downstream effect is blocked. Loading showed success by having an inhibitory effect on a nerve impulse. With a range of electrical voltages from 2. NV to 4. 0 NV, no action potential was shown. This is what an inhibitory chemical intends to do inhibit any response by binding to the axon terminals of the presentation neuron. Specifically, it blocks the voltage-gated sodium channels that allow the influx of sodium when the nerve reaches the threshold voltage thus preventing an action potential. No action potential means no nerve impulse. A nerve must be stimulated and that stimulation must meet or exceed the threshold le vel required for activity to follow. Then as an impulse occurs, such as the nerve with loading being stimulated there must be either a period of inhibition or excitement that causes the membranes permeability to change. If a stimulation was intended to be excitatory the process of generating an action potential would occur, followed by revitalization and hyperventilation. However, in inhibitory responses, the goal is to see no action potential. If the intention is to prevent a stimulus from occurring, creating an action potential is not desired. It is important to understand the properties of substances such as these to better understand their intended effect. In order for them to be used properly one must know what intention of these substances to then provide a proper use for them. For example, one WOUld not propose to administer loading to someone who has regular heart function, because that would suppress their art levels below the threshold level. In conclusion nerve impulses all begin with a stimulus that either causes excitement or inhibition from a certain stimulus (Marine MitcheIl, 2009). If a nerve is excited the process of creating an action potential follows in order to achieve a chemical synapse. In other words, when a nerve is stimulated certain messages able to be transported in and out of the cell. However, in an inhibitory response such as the one witnessed with loading. This experiment determined the difference in excitatory versus inhibitory stimuli in a nerve. It allowed us to visualize the synaptic activity occurring based on a certain chemical which allows us to better understand the effects certain substances have on nerves.

Lord of the Flies Themes, Symbols, and Literary Devices

Lord of the Flies Themes, Symbols, and Literary Devices Lord of the Flies, William Goldings tale of British schoolboys stranded on a deserted island, is nightmarish and brutal. Through its exploration of themes including good versus evil, illusion versus reality, and chaos versus order, Lord of the Flies raises powerful questions about the nature of humankind. Good vs. Evil The central theme of Lord of the Flies is human nature: are we naturally good, naturally evil, or something else entirely? This question runs through the entire novel from beginning to end. When the boys gather on the beach for the first time, summoned by the sound of the conch, they have not yet internalized the fact that they are now outside the normal bounds of civilization. Notably, one boy, Roger, remembers throwing stones at younger boys but deliberately missing his targets for fear of retribution by adults. The boys decide to set up a democratic society in order to maintain order. They elect Ralph as their leader and create a crude mechanism for discussion and debate, designating that anyone who holds the conch has the right to be heard. They build shelters and show concern for the youngest among them. They also play make believe and other games, exulting in their freedom from chores and rules. Golding seems to suggest that the democratic society they create is simply another game. The rules are only as effective as their enthusiasm for the game itself. It is notable that at the beginning of the novel, all the boys assume rescue is imminent, and thus that the rules theyre accustomed to following will soon be reimposed. As they come to believe that they will not be returned to civilization anytime soon, the boys abandon their game of democratic society, and their behavior becomes increasingly fearful, savage, superstitious, and violent. Golding’s question is perhaps not whether humans are inherently good or evil, but rather whether these concepts have any true meaning. While it is tempting to see Ralph and Piggy as ‛good’ and Jack and his hunters as ‛evil,’ the truth is more complex. Without Jack’s hunters, the boys would have suffered hunger and deprivation. Ralph, the believer in rules, lacks authority and the ability to enforce his rules, leading to disaster. Jack’s rage and violence leads to the destruction of the world. Piggy’s knowledge and book learning are proven as to be meaningless as his technology, represented by the fire-starting glasses, when they fall into the hands of boys who do not understand them. All of these issues are mirrored subtly by the war that frames the story. Although only vaguely described, it is clear that the adults outside the island are engaged in a conflict, inviting comparisons and forcing us to consider whether the difference is merely a matter of scale. Illusion vs. Reality The nature of reality is explored in several ways in the novel. On the one hand, appearances seem to doom the boys to certain roles- most notably Piggy. Piggy initially expresses the dim hope that he can escape the abuse and bullying of his past through his alliance with Ralph and his usefulness as a well-read child. However, he quickly falls back into the role of the bullied ‛nerd’ and becomes reliant on Ralph’s protection. On the other hand, many aspects of the island are not clearly perceived by the boys. Their belief in The Beast stems from their own imaginations and fears, but it quickly takes on what seems to the boys to be a physical form. In this way, The Beast becomes very real to the boys. As the belief in The Beast grows, Jack and his hunters descend into savagery. They paint their faces, changing their appearance in order to project a fearsome and frightening visage that belies their true childish nature. More subtly, what seemed real in the beginning of the book- Ralph’s authority, the power of the conch, the assumption of rescue- slowly erodes over the course of the story, revealed to be nothing more than the rules of an imaginary game. In the end, Ralph is alone, there is no tribe, the conch is destroyed (and Piggy murdered) in the ultimate refutation of its power, and the boys abandon the signal fires, making no effort to prepare for or attract rescue. At the terrifying climax, Ralph is hunted through the island as everything burns- and then, in a final twist of reality, this descent into horror is revealed to be unreal. Upon discovering they have in fact been rescued, the surviving boys immediately collapse and burst into tears. Order vs. Chaos The civilized and reasonable behavior of the boys at the beginning of the novel is predicated on the expected return of an ultimate authority: adult rescuers. When the boys lose faith in the possibility of rescue, their orderly society collapses. In a similar way, the morality of the adult world is governed by a criminal justice system, armed forces, and spiritual codes. If these controlling factors were to be removed, the novel implies, society would quickly collapse into chaos. Everything in the story is reduced to its power or lack thereof. Piggy’s glasses can start fires, and thus are coveted and fought over. The conch, which symbolizes order and rules, can challenge raw physical power, and so it is destroyed. Jack’s hunters can feed hungry mouths, and thus they have an outsize influence over the other boys, who quickly do as they are told despite their misgivings. Only the return of adults at the end of the novel changes this equation, bringing a more powerful force to the island and instantly reimposing the old rules. Symbols On a superficial level, the novel tells a story of survival in a realistic style. The process of building shelters, gathering food, and seeking rescue are recorded with a high level of detail. However, Golding develops several symbols throughout the story that slowly take on increasing weight and power in the story. The Conch The Conch comes to represent reason and order. In the beginning of the novel, it has the power to quiet the boys and force them to listen to wisdom. As more boys defect to Jack’s chaotic, fascist tribe, the Conchs color fades. In the end, Piggy- the only boy who still has faith in the Conch- is killed trying to protect it. The Pig’s Head The Lord of the Flies, as described by a hallucinating Simon, is a pig’s head on a spike being consumed by flies. The Lord of the Flies is a symbol of the increasing savagery of the boys, on display for all to see. Ralph, Jack, Piggy, and Simon Each of the boys represent fundamental natures. Ralph represents order. Piggy represents knowledge. Jack represents violence. Simon represents good, and is in fact the only truly selfless boy on the island, which makes his death at the hands of Ralph and the other supposedly civilized boys shocking. Piggy’s Glasses Piggy’s glasses are designed to provide clear vision, but they are transformed into a tool to make fire. The glasses serve as a symbol of control more powerful than the Conch. The Conch is purely symbolic, representing rules and order, while the glasses convey true physical power. The Beast The beast represents the unconscious, ignorant terror of the boys. As Simon thinks, The beast is the boys. It did not exist on the island before their arrival. Literary Device: Allegory Lord of the Flies is written in a straightforward style. Golding eschews complex literary devices and simply tells the story in chronological order. However, the entire novel serves as a complex allegory, in which every major character represents some larger aspect of society and the world. Thus, their behavior is in many ways predetermined. Ralph represents society and order, and so he consistently attempts to organize and hold the boys to standards of behavior. Jack represents savagery and primitive fear, and so he consistently devolves to a primitive state.

Value at risk Assignment Example | Topics and Well Written Essays - 3750 words

Value at risk - Assignment Example Value at risk provides a way to depict the probability of on making losses. In the paper below, various methodologies are going to be used to calculate the value at risk of the 4 portfolio shares for the given year. The methodologies that would be use include: The historical simulation, the Monte Carlo simulation and the parametric approach. In each of the following, there are various crucial steps that would be used in calculation of value at risk in the value at risk to come up with conclusions for the various portfolio shares. The structure of the paper would mostly be description based of the following approaches mentioned above. While calculating value at risk in a specific methodology, the following will need to be observed carefully. In each methodology, a description on how one is going to arrive at the specific value at risk for the given portfolio is going to be calculated and even a histogram plotted where necessary. In addition, one would be expected to comment on the important steps used and give a final verdict of the advantages and the disadvantages of using the given method. After calculating value at risk using the three approaches mentioned above, then a discussion will be conducted to compare the differences in the three methods while attempting to get the value at risk (Jorion 2007, p.6). Then the paper would end with a conclusion that would comment on the value at risk of the 4 portfolio shares used. ... cause the end product of any of the two approaches will be to estimate value at risk, often the most important points remain on whether results calculated by other different methods may differ from each other. In addition, one would still like to know which approach is the most reliable in estimating value at risk. Generally, intuitiveness shows that non-parametric methods, like the historical simulation as well as the parametric methods i.e. Risk metrics, will often yield the same Value at risk if historical returns data will be normally distributed. In addition, empirical studies also shown that the given predicted results from different Value at risk methodologies are often not close (Choudhry 2006, p.7. The historical simulation often does not impose a given distributional assumptions, sometimes it can be limited when used to forecast the range of certain portfolio value changes since it incorporates no volatility updating plus it produces inaccurate values once the future succum bs to extreme events. In contrast, the Risk metrics, is relatively easy to put in practice. Nonetheless, a given empirical observations on a given returns of financial instruments often do not exhibit the given normal distribution and hence the method do not fit data with certain heavy tails. Background to the data sample The following 4 companies have been chosen to have the analysis of their value at risk of their share portfolios calculated. They are Aggreko PLC, Admiral Group PLC, Amec PLC and the Anglo- American PLC. The Aggreko PLC is a very large international company that deals with supplying temporary power plus dealing with temperature control too. Admiral Group PLc is a large motor insurance company that has a head office at Wale, Cardiff . The Amec PLC is hence a global